Broadly speaking the journal of pharmacokinetics and pharmacodynamics covers the area of pharmacometrics the journal is devoted to illustrating the importance of pharmacokinetics pharmacodynamics and pharmacometrics in drug development clinical care and the understanding of drug action the journal publishes on a variety of topics related to pharmacometrics including but not limited to . Biopharmaceutics drug disposition publishes original review articles short communications and reports in biopharmaceutics drug disposition pharmacokinetics and pharmacodynamics especially those that have a direct relation to the drug discovery development and the therapeutic use of drugs biopharmaceutics drug disposition is one of the top accessed and cited journals in the field as . Biopharmaceutics and pharmacokinetics dosage regimen the manner in which the drug should be taken this obviates the use o f the empirical approach where a considerable experi mentation is needed to arrive at the balance between the desired therapeutic and the undesired toxic effects in order to define an appropriate dosage regimen. Its possible to do this and more with the gastroplus pbpk modeling platform gastroplus is a mechanistically based simulation software package that simulates intravenous oral oral cavity ocular inhalation dermal subcutaneous and intramuscular absorption biopharmaceutics pharmacokinetics and pharmacodynamics in humans and animals. Modeling and simulation offer a path to establish this link in this regard physiologically based modeling has been implemented successfully to support regulatory decision making and drug product labeling in this manuscript case studies of physiologically based biopharmaceutics modeling pbbm applied to drug product quality are presented and summarized these case studies exemplify a
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